MODERN DNA LABORATORY ADDRESS:
Molecular Population Genetics
Smurfit Institute of Genetics
Trinity College Dublin
Dublin 2
Ireland
ANCIENT DNA LABORATORY ADDRESS (for archaeological samples):
Archaeological Genetics
Smurfit Institute of Genetics
Trinity College Dublin
Dublin 2
Ireland
RESEARCH INTEREST:
Ancient DNA research allows changes in the genomes of organisms to be studied over archaeological timescales. This field has been revolutionized by the invent of next generation sequencing technologies, which have allowed the publication of four ancient nuclear genomes. Using these methods we are re-sequencing both the mitochondrial and targeted regions of the nuclear genome of multiple domesticate species (Cow, Sheep and Goat). Results from this analysis have the ability to inform on the effects of domestication on these species. This work is funded by the European training network LeCHE which seeks to uncover the effects of milk use in Europe. We therefore have a special interest in studying genes linked to milk production and SNPs that are informative for dairy-associated biological change in cattle through time.
ACADEMIC CAREER:
2012 to date : Research Assistant, Trinity College Dublin
Next generation sequencing of aDNA and the population genetics of domestication.
EDUCATION & QUALIFICATIONS:
2008-2012:Ph.D. Genetics, Trinity College Dublin
Thesis title : Next generation sequencing of ancient DNA
2007-2008: MRes Bioinformatics, Newcastle University.
Thesis title :Searching for similarities between genomes of flu viruses and the chicken (Gallus gallus) genome
Supervisor: Dr Peter Andras
2004-2007: Bsc (Hons) Human Genetics, Newcastle University.
Thesis title :Examining the spatial distribution of a novel FHA and RING finger protein and its interacting proteins in spermatogenesis
Supervisor: Dr Rachel Davies
EMPLOYMENT EXPERIENCE:
June 2006 – August 2006 : Wellcome Trust Vacation Scholarship 8 Weeks. Newcastle University.
Type III secretion of virulence effecter proteins in Salmonella: Signal sequences and molecular mechanisms.
Supervisor: Dr CMA Khan
October 2005 - June 2006 : Student Lab Assistant. Newcastle University.
Supervisor: Dr CMA Khan
PUBLICATIONS:
Teasdale MD, Bradley DG.
The origins of cattle.
In: Womack JE, ed.Bovine Genomics. Ames: Wiley-Blackwell. 284 p.
PRESENTATIONS:
Teasdale MD,Stock F, Bradley DG.
Next generation sequencing of Bovine Nuclear aDNA: Applications for selection and migration
LeCHE - Lactase persistence and the early Cultural History of Europe, VU University Amsterdam, The Netherlands, 28-29 June 2012
Teasdale MD, Bradley DG.
Next generation sequencing of ancient DNA
2nd Irish Next-Gen Sequencing/Bioinformatics Meeting,Trinity Biomedical Sciences Institute (TBSI), Pearse Street, TCD, Dublin 2. 31st May 2012
Teasdale MD,Stock F, Bradley DG.
Next generation sequencing of ancient animal domesticates
The Rank Prize Funds Mini-Symposium on Evolution of the Human Diet, 9th to 12th May 2011
Teasdale MD, Lau LPL, Bradley DG.
Markings of positive selection and domestication in the bovine genome.
[Poster] VIBE Meeting (Virtual Institute of Bioinformatics Éire),
University College Cork, Cork, Ireland, 17th September 2010
Teasdale MD, Lau LPL, Bradley DG.
Markings of positive selection and domestication in the bovine genome.
[Poster] 11th International Conference of the International Council for Archaeozoology, Pierre et Marie Curie University, Paris, France, 23-28 August 2010
OTHER MERITS:
As undergraduate: Wellcome Trust Biomedical Vacation Scholarship
