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Selected Bracken Lab Publications:

Deevy O and Bracken AP. PRC2 functions in development and congenital disorders. Development. 2019. In press.

Healy E, Mucha M, Glancy E, Fitzpatrick DJ, Conway E, Neikes HK, Monger C, Van Mierlo G, Baltissen MP, Koseki Y, Vermeulen M, Koseki H, and Bracken AP. PRC2.1 and PRC2.2 synergize to co-ordinate H3K27 tri-methylation. Molecular Cell. 2019. Online on September 11.

Bracken AP, Brien GL and Verrijzer CP. Dangerous Liaisons: Interplay between SWI/SNF, NuRD and Polycomb in Chromatin Regulation and Cancer. Genes & Development. 2019. 33:1-24.

Brien GL, Bracken AP. The 3D Genome: EZH2 Comes into the Fold. Trends Mol Med. 2019. 25(5):362-365.

Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Molecular Cell. 2018 May 3;70(3):408-421.

Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP*, Cagney G*. The H3K36me2 methyltransferase Nsd1 Demarcates PRC2-mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells. Molecular Cell. 2018. 70(2). 371–379. (*both equal, last authors).

Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Manuwar N, Watson A, Wynne K, Negri G, Dillon ET, Jammula S, Hokamp K, O'Connor DP, Pasini D, Cagney G, Bracken AP. Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. EMBO J. 2017. 36(15):2216-2232.

Erceg J, Pakozdi T, Marco-Ferreres R, Ghavi-Helm Y, Girardot C, Bracken AP, Furlong EMM. Dual functionality of cis-regulatory elements as developmental enhancers and polycomb response elements. Genes & Development. 2017. March 15; 31 (6):590-602.

Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade S, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP. A chromatin independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence. Genes & Development. 2015 Nov 1;29(21):2231-43.

Conway E, Healy E, Bracken AP. PRC2 mediated H3K27 methylations in cellular identity and cancer. Current Opinion in Cell Biology. 2015. Oct 22;37:42-48.

Streubel G, Bracken AP. MED23: a new Mediator of H2B monoubiquitylation. EMBO J. 2015. 34, 2863-2864. 

Aloraifi F, McDevitt T, Martiniano R, McGreevy J, McLaughlin R, Egan CM, Cody N, Meany M, Kenny E, Green AJ, Bradley DG, Geraghty JG, Bracken AP. Detection of novel germline mutations for breast cancer in non-BRCA1/2 families. FEBS J. 2015. 282 (17): 3424-37.

Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GF, Helin K, Holmberg J, Bracken AP. CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and Polycomb gene repression. Developmental Cell. 2013. 26 (3): 223-236.

Turner, SA and Bracken AP. A “Complex” Issue: Deciphering the Role of Variant PRC1 in ESCs. Cell Stem Cell. 2013. 12 (2): 145-146.

Brien GL, Gambero G, O'Connell D, Jerman E, Turner S, Egan C, Dunne E, Jurgens M, Wynne K, Piao L, Amanda J. Lohan A, Neil Ferguson N, Shi X, Sinha K, Loftus BJ, Cagney G, Bracken AP. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.  Nature Structural & Molecular Biology. 2012. 19 (12): 1273-81.

Lanigan F, Geraghty JG, Bracken AP. Transcriptional regulation of cellular senescence. Oncogene. 2011. 30 (26): 2901-11.

 

Selected Post-doctorate Publications:

Bracken AP and Helin K. Polycombs: Navigators of lineage pathways led astray in cancer. Nature Reviews Cancer. 2009. 9 (11): 773-84.

Hansen KH, Bracken AP, Pasini D, Dietrich N, Gehani SS, Monrad A, Rappsilber J, Lerdrup M, Helin K. A model for transmission of the H3K27me3 epigenetic mark. Nature Cell Biology. 2008. 10 (11): 1291-300.

Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Monch K, Minucci S, Porse BT, Marine JC, Hansen KH and Helin K. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent Cells. Genes & Development. (2007). 21(5): 525-30.

Pasini D, Bracken AP, Hansen JB, Capillo M and Helin K. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol. 2007 (10): 3769-79.

Bracken AP, Dietrich N, Pasini D, Hansen KH and Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development. 2006. 20 (9): 1123-36.

Bracken AP, Ciro M, Cocito A and Helin K. E2F target genes: unravelling the biology. Trends Biochem. Sci. 2004. 29 (8): 409-17.

Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 2003. 22 (20): 5323-35.

 
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