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Welcome to the Bracken Lab homepage

The group is led by Adrian Bracken and was established in 2008 at the Smurfit Institute of Genetics, Trinity College Dublin. We are studying the molecular mechanisms of stem cells and cancer. Our papers include a study on the role of Polycomb group proteins in embryonic stem cells, the role of the tumour suppressor, CHD5, during neurogenesis and a new chromatin independent role of Polycomb-like 1 in the p53 pathway. More recently, we  demonstrated a antagonistic interplay between the H3K36me2 and H3K27me3 histone modifications and discovered a new family of proteins that encode vertebrate specific Polycomb proteins.

Click here to watch our Webinar on "The role of Polycombs in Cancer" or read a related review on the role of Histone H3K27 methylations in cellular identity and cancer.

 
Website Developed by Naisha Shah (naishas@gmail.com)